Intranasal delivery of nerve growth factor attenuates aquaporins-4-induced edema following traumatic brain injury in rats

Q Lv, X Fan, G Xu, Q Liu, L Tian, X Cai, W Sun, X Wang… - Brain research, 2013 - Elsevier
… Here we further studied whether intranasal NGF could attenuate TBI-induced brain edema
and … We found that intranasal administration of NGF (5 μg/d) attenuated the brain edema, as …

Aquaporin 4 in traumatic brain injury: from molecular pathways to therapeutic target

E Dadgostar, S Rahimi, S Nikmanzar, S Nazemi… - Neurochemical …, 2022 - Springer
… -1 α (HIF-1 α) sirtuin 2, NF-κB, Malat1, nerve growth factor … shown to attenuate brain edema,
maintain blood–brain barrier … vascular endothelial growth factor (VEGF) upon brain injury [63]…

[HTML][HTML] Intranasal nerve growth factor for prevention and recovery of the outcomes of traumatic brain injury

L Manni, G Conti, A Chiaretti… - Neural Regeneration …, 2023 - journals.lww.com
… with nerve growth factor, intranasally delivered to the brain … Moreover, NGF intranasal
treatment in AD transgenic mice … , attenuating, among others, the effects of proNGF on hp-tau. …

Mildly reduced brain swelling and improved neurological outcome in aquaporin-4 knockout mice following controlled cortical impact brain injury

X Yao, K Uchida, MC Papadopoulos, Z Zador… - Journal of …, 2015 - liebertpub.com
Brain edema following traumatic brain injury (TBI) is associated with considerable morbidity
… In a recent study, intranasal administration of nerve growth factor reduced brain edema after

Acute intranasal treatment with nerve growth factor limits the onset of traumatic brain injury in young rats

L Manni, E Leotta, I Mollica, A Serafino… - British Journal of …, 2023 - Wiley Online Library
Intranasal delivery of nerve growth factor attenuates aquaporins-4-induced edema
following traumatic brainIntranasal administration of nerve growth factor ameliorate beta-amyloid …

Intranasal nerve growth factor attenuates tau phosphorylation in brain after traumatic brain injury in rats

Q Lv, W Lan, W Sun, R Ye, X Fan, M Ma, Q Yin… - Journal of the …, 2014 - Elsevier
… On this basis, our team has done a series of research about the effect of NGF on TBI rats. We
found that intranasal delivery of NGF, started at 6 h after TBI, attenuates the brain edema [12…

Aquaporin-4 expression in cultured astrocytes after fluid percussion injury

KVR Rao, PVB Reddy, KM Curtis… - Journal of …, 2011 - liebertpub.com
… B rain edema is a major complication of traumatic brain injury (TBI). A consequence of …
Curcumin attenuates cerebral edema following traumatic brain injury in mice: a possible role for …

[HTML][HTML] Intranasal delivery of nerve growth factor in neurodegenerative diseases and neurotrauma

L Manni, G Conti, A Chiaretti, M Soligo - Frontiers in pharmacology, 2021 - frontiersin.org
… In astrocytes, NGF/p75NTR interaction attenuates the … of AD, using NGF brain-deprived
mice (AD11 mice), or multiple-… “Nerve growth factor in pediatric severe traumatic brain injury: …

[HTML][HTML] Immunohistochemical evaluation of aquaporin-4 and its correlation with CD68, IBA-1, HIF-1α, GFAP, and CD15 expressions in fatal traumatic brain injury

M Neri, A Frati, E Turillazzi, S Cantatore… - International journal of …, 2018 - mdpi.com
brain injury, brain edema almost always occurs and is heavily involved in the pathophysiology
of brain damage following traumatic injury… that vascular endothelial growth factors (VEGF), …

[HTML][HTML] Intranasal delivery: effects on the neuroimmune axes and treatment of neuroinflammation

EM Rhea, AF Logsdon, WA Banks, ME Erickson - Pharmaceutics, 2020 - mdpi.com
intranasal delivery of various compounds from growth factors to … Nerve growth factor (NGF)
is a neurotrophin that aids in … delivered intranasally and attenuated dopaminergic neuron loss …